Research Staff
Chuck Klanke
Title
Senior Research Assistant and Lab Manager, Center for Molecular Fetal Therapy
Email
chuck.klanke@cchmc.org
Phone
513-636-9663
Fax
513-636-9665
Credentials
BS: Biomedical Sciences, Grand Valley State University, Allendale, MI
MS: Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH
Position History
2005 - 2007: Senior Research Assistant, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
2003 - 2005: Senior Research Assistant and Lab Manager, Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
2000 - 2003: Principal Researcher, Anti-Infectives Biology, Proctor & Gramble Pharmaceuticals, Cincinnati, OH
Publications, Most Recent
Layh-Schmitt, G., Rosenstiel. A, Wang, W., Koch, S., Wittlinger, C., Kraft, E., Klanke, C., Bailey, J., Jansen, M., McCaffery, P., v. Kalle, C.. An LMO2 associated Transcription complex activates a truncated form of retinaldehyde dehydrogenase in T cell acute lymphoblastic leukemia (T-ALL), submitted for publication.
Parvadia, J.K., Maldonado, A.R., Morris, L.M., Vulentin-Solis, J.F., Ripberger, M., Kalinowska, B., Lim, F.Y., Crombleholme, T.M. Stem Cell Factor Rescues Ang-1 Mediated Endothelial Progenitor Cell Mobilization in Diabetic Mmp-9-KO Mice. Society of University Surgeons, Abstract, 2008.
Deichmann A, Hacein-Bey-Abina S, Schmidt M, Garrigue A, Brugman MH, Hu J, Glimm H, Gyapay G, Prum B, Fraser CC, Fischer N, Schwarzwaelder K, Siegler ML, de Ridder D, Pike-Overzet K, Howe SJ, Thrasher AJ, Wagemaker G, Abel U, Staal FJ, Delabesse E, Villeval JL, Aronow B, Hue C, Prinz C, Wissler M, Klanke C, Weissenbach J, Alexander I, Fischer A, von Kalle C, Cavazzana-Calvo M. Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy.J Clin Invest. 2007 Aug;117(8):2225-32.
Evdokimov AG, Pokross M, Walter RL, Mekel M, Barnett BL, Amburgey J, Seibel WL, Soper SJ, Djung JF, Fairweather N, Diven C, Rastogi V, Grinius L, Klanke C, Siehnel R, Twinem T, Andrews R, Curnow A. Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins. 2007 Feb 15;66(3):538-46.
Nowrouzi A, Dittrich M, Klanke C, Heinkelein M, Rammling M, Dandekar T, von Kalle C, Rethwilm A. Genome-wide mapping of foamy virus vector integrations into a human cell line.J Gen Virol. 2006 May;87(Pt 5):1339-47.
Layh-Schmitt, G., S. Crable, K. Crable, E. Kraft, J. Bailey, C. Klanke, C. v. Kalle. T cell acute lymphoblastic leukemia originates from a differentiation block in T cell development due to aberrant expression of LMO2 and TAL1(SCL). Blood, 106, 628. 48th ASH Annual Meeting, Orlando, FA, USA, Abstract, 2006.
Kraft E., S. Crable, K. Crable, J. Bailey, C. Klanke, C. v. Kalle, G. Layh-Schmitt. LMO2 induced T cell acute lymphoblastic leukemia originates from a differentiation block in T cell development.5th Annual Midwest Blood Club meeting, Cincinnati OH, USA, Abstract, 2006.
Layh-Schmitt, G., W. Wang, A. Rosenstiel, C. Wittlinger, C. Klanke, J. Bailey, K. Crable, S. Crable, C. v. Kalle. LMO2 induced T cell acute lymphoblastic leukemia originates from a differentiation block in T cell development.4th Annual Midwest Blood Club meeting, Lexington KY, USA, Abstract, 2006.
Greis KD, Zhou S, Siehnel R, Klanke C, Curnow A, Howard J, Layh-Schmitt G. Development and validation of a whole-cell inhibition assay for bacterial methionine aminopeptidase by surface-enhanced laser desorption ionization-time of flight mass spectrometry. Antimicrob Agents Chemother. 2005 Aug;49(8):3428-34.
Layh-Schmitt, G., W. Wang, A. Rosenstiel. S. Koch, C. Klanke, K. Anderson, P. McCaffery. RALDH2 is regulated by an LMO/SCL(TAL1) associated protein complex in T cell acute lymphoblastic leukemia.47th ASH Annual Meeting, Atlanta, GA, USA, Abstract, 2005.
Layh-Schmitt, G., W. Wang, A. Rosenstiel, C. Klanke, K. Bohn, C. von Kalle. Molecular mediators of T-cell leukemia in a patient after gene therapy for X-SCID. 3rd Annual Midwest Blood Club meeting, Louisville, KY, USA, Abstract, 2005.
Layh-Schmitt, G., A. Rosenstiel, C. Klanke, K. Bohn, C. von Kalle. Towards the mechanism of LMO2 associated T-cell leukemia.6th International Symposium and Expert Workshops on Leukemia and Lymphoma, Amsterdam, Netherlands, 2005.
