Cardiothoracic Surgery

Pirooz Eghtesady, MD, PhD

Appointment

Associate Professor of Surgery, University of Cincinnati College of Medicine

Email

pirooz.eghtesady@cchmc.org

Phone

513-636-4770

Fax

513-636-3847

Bio

Presently – We are conducting extensive translational studies toward developing and applying clinically applicable protocols for maternal-fetal cardiac intervention and surgery. We are also studying the potential utility of natriuretic peptides as biomarkers of fetal cardiovascular well-being and as a candidate selection marker for fetal cardiac intervention. The research in our laboratory is conducted in a multidisciplinary fashion with close collaboration with Dr. Kenneth Clark at University of Cincinnati, Department of Obstetrics and Gynecology. Simultaneous with our maternal-fetal cardiac surgery studies, we have developed and continue to study ovine fetal models of various congenital heart diseases to better understand the physiology and mechanisms underlying in utero evolution of these lesions. Our laboratory has placed a particular emphasis on fetal aortic stenosis and Hypoplastic Left Heart Syndrome (HLHS) as the primary lesions of interest. Along those lines we are simultaneously conducting clinical and epidemiologic studies to better understand potential etiologic mechanisms in these diseases. Most recently, our laboratory has been focusing on a novel hypothesis implicating the potential role of maternal strep exposure in pathogenesis of HLHS (i.e. a form of rheumatic heart disease in the fetus). Concomitant with the preceding basic and translation research, we are also involved with several clinical research projects, including in a multi-institutional NIH sponsored U01 project conducted by the Pediatric Heart Network, studying the optimal surgical therapy for newborns affected by HLHS.

Credentials

MD / PhD: Molecular Biology and Immunology UCLA, School of Medicine 1987-1993.

BS / MS: Biochemistry, UCLA 1983-1987.

Minor, Physics: California State University, Fresno 1991-1993.

Residency: Stanford University Hospital 1993-1998, Resident in General Surgery.

Residency: Johns Hopkins Hospital 1998-2001, Resident in Cardiothoracic Surgery.

Fellowship: Broussais Hospital, Paris, France 1999, Professor Alain Carpentier's
Service, Fellow in Cardiovascular Surgery.

Fellowship: UCSF / Stanford University Hospital 2001-2002, Fellow in Pediatric Cardiac Surgery.

Fellowship: Marie Lannelongue Hospital, Paris, France 1999, Professor Claude Planche's Service, Fellow in Pediatric Cardiac Surgery.

Position History

2002 - Present: Assistant Professor of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Awards and Honors

International Conf of Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion, 2005, Hershey, PA
John Waldhausen, MD- Young Investigator Award

American Academy of Pediatrics, 2003, New Orleans, LA
Cardiology and Cardiac Surgery Section
1st Place, Basic Sciences - Young Investigator Award

Perinatal Research Society, 2003, Charleston SC
NIH Young Investigator Travel Award

Johns Hopkins Hospital
Vincent L. Gott Award, 2000

Stanford University Hospital
John Henry Smith Award, 1997

UCLA, School of Medicine
AOA
Alumni Achievement Award
Mandel Scholarship
Teaching Recognition Award, 1992, 1993
NIH Tumor Immunology Fellowship Award
NIH M.S.T.P. Fellowship Award

UCLA
Departmental Scholar Medal (Biochemistry)
Departmental Honors (Chemistry and /Biochemistry)
College Honors Research Award
Alumni Association Achievement Award

Research

Dr. Eghtesady's Laboratory is actively involved in developing and studying animal models of congenital heart disease, to better understand the mechanisms underlying in utero evolution of these lesions. Further, we are using these models to develop techniques for fetal cardiac surgery/intervention.

1/2000 - 6/2001 Clinical Research, Is Atrial Fibrillation Post Cardiac Surgery Iatrogenic? a Retrospective Review and Analysis of Atrial Fibrillation among Patients >65 Years of Age after Elective Primary CABG, Johns Hopkins Hospital, Baltimore, MD

1/2000 - 6/2000 Clinical Research, Is Barrett's Adenocarcinoma a Genetically Mediated Disease in Women?a Retrospective Review under the guidance of Dr. Richard Heitmiller, Dept. of Surgery, Div. of Thoracic Surgery

7/1999 - 1/2000 Clinical Research, Retrospective Review and Analysis of Management of Patients with Tetrology of Fallot under Three Months of Age: Repair, Dilate, or Shunt?under the guidance of Professor Francois Lacour-Gayet, Marie Lannelongue Hospital, Paris, France

7/1999 - 1/2000 Basic Research, Cardioscopic Cardiac Surgery, under the guidance of Professor Alain Carpentier, Broussais Hospital, Paris, France, Dept. of Cardiovascular Surgery

Research Grants and Contracts

A list of Dr. Eghtesady's most recent grants can be found on his lab web site.

Publications, Most Recent

Book Chapter

Peer-Reviewed Articles

Reed CA, Baker RS, Lam CT, Hilshorst J, Lombardi J, Ferguson R, Eghtesady P. Application of Near-Infrared Spectroscopy during Fetal Cardiac Surgery. Journal of Surgical Research 2009. [In Press]

Petrucci O, Khoury PR, Manning PB, Eghtesady P. Outcomes of Bidirectional Glenn in Patients less than 3 months of age. J Thorac Cardiovasc Surg 2009 Nov 10. [Epub ahead of print]

Anderson JB, Beekman RH 3rd, Border WL, Kalkwarf HJ, Khoury PR, Uzark K, Eghtesady P, Marino BS. Lower weight-for-age z score adversely affects hospital length of stay after the bidirectional Glenn procedure in 100 infants with a single ventricle. J Thorac Cardiovasc Surg 2009;138(2):397-404.e1. Epub 2009 May 23.

Baker RS, Lam CT, Heeb EA, Eghtesady P. Dynamic fluid shifts induced by fetal bypass. J Thorac Cardiovasc Surg 2009;137(3):714-22.

Heeb EA, Baker RS, Lam C, Basu M, Lubbers W, Duffy JY, Eghtesady P. Role of natriuretic peptides in cGMP production in fetal cardiac bypass. Ann Thorac Surg 2009;87(3):841-7.

Ashcraft TM, Jones K, Border WL, Eghtesady P, Pearl JM, Khoury PR, Manning PB. Factors affecting long-term risk of aortic arch recoarctation after the Norwood procedure. Ann Thorac Surg 2008;85(4):1397-401; discussion 1401-2.

Lam CT, Sharma S, Baker RS, Hilshorst J, Lombardi J, Clark KE, Eghtesady P. Fetal stress response to fetal cardiac surgery. Ann Thorac Surg 2008;85(5):1719-27.

Baker RS, Lam CT, Heeb EA, Hilshorst JL, Ferguson R, Lombardi J, Eghtesady P. A simple solution is "prime" for fetal cardiopulmonary bypass. ASAIO J 2007;53(6):710-5.

Lam C, Baker RS, McNamara J, Ferguson R, Lombardi J, Clark K, Eghtesady P. Role of Nitric Oxide in Placental Dysfunction following Fetal Bypass. Annals of Thoracic Surgery 2007;84(3):917-24; discussion 924-5.

Gardner A, Eghtesady P. Infant Arch Reconstruction during Total System Perfusion. The Journal of Thoracic and Cardiovascular Surgery 2007;133(4):1096-1098.

Lubbers WC, Eghtesady P. Fetal aortic stenosis and changes in amniotic fluid natriuretic peptides. Am J Obstet Gynecol 2007;196:253.e1-253.e6.

Eghtesady P, Altaye M, Ballard E, Beekman R, Hirsch R, Michelfelder E. Revisiting Animal Models of Aortic Stenosis in the Early Gestation Fetus. Annals of Thoracic Surgery 2007;83:631-639.

Lombardi J, Sedgwick J, Schenbeck J, Lubbers W, Ferguson RE, Gardner A, McNamara JL, Eghtesady P. Cardiopulmonary Bypass in the Immature Fetus Through a Novel Use of a Mini-Centrifugal Pump. Perfusion 2006;21(3):185-91.

Eghtesady P, Sedgwick J, Schenbeck J, Lam C, Lombardi J, Ferguson R, Gardner A, McNamara J, Manning P. Maternal-fetal Interactions In Fetal Cardiac Surgery. Annals of Thoracic Surgery 2006;81(1):249-56, discussion 255-6.

Eghtesady P. Hypoplastic Left Heart Syndrome: Rheumatic Heart Disease of the Fetus? Med Hypothesis 2006;66:554-565.

Presentations, Most Recent

EghtesadyP. Moderator: Pediatrics and Developmental Biology 2: Pathways in Development and Disease. Society of University Surgeons. 4th Annual Academic Surgical Congress. Ft. Myers, FL. February, 2009

EghtesadyP, Baker RS, Lam CT, Basu M, Clark KE. Role of Nitric Oxide in the Increased Vascular Resistance Following Fetal Cardiac Bypass. American Heart Association Research Symposium. New Orleans, LA. November, 2008.

Eghtesady P. Ventricular Septal Defects. Thoracic Teaching Program. University of Cincinnati, Cincinnati, OH. October, 2008

Eghtesady P. Management and Career Planning Tools. Cardiology Fellows Staff Meeting. Children’s Hospital Medical Center, Cincinnati, OH. June, 2008.

Eghtesady P. Vascular Rings. Pediatric Surgery Grand Rounds. Children’s Hospital Medical Center, Cincinnati, OH. February, 2008.

Eghtesady P. BTs, PABs, and Other Palliations. Cardiac Intensive Care Unit In Service, Children's Hospital Medical Center, Cincinnati, OH, November 2007.

Eghtesady P. Hypoplastic Left Heart Syndrome: An Update. Pediatric Cardiology Grand Rounds, Le Bonheur Children's Hospital, Memphis, TN, June 2007.

Eghtesady P, Baker RS, Lam C, Heeb E, Lubbers W, McNamara J, Ferguson R, Gardner A, Lombardi J. A Simple Solution is “Prime” for Fetal Cardiopulmonary Bypass. Third International Conference on Pediatric Mechanical Circulatory Support systems and Pediatric Cardiopulmonary Perfusion. Hershey, PA. May 17-19, 2007.

Eghtesady P. Modified Norwood Palliation with Systemic Myocardial Perfusion during Arch Reconstruction. ODICH Conference, Cincinnati, OH, May 2007.

Eghtesady P. Latest Advances with the Norwood Procedure. Pediatric Cardiac Anesthesia Conference, Children's Hospital Medical Center, Cincinnati, OH February 2007.

Eghtesady P. Fetus with Heart Disease. University of Cincinnati, Department of Obstetrics and Gynecology Research Conference, Cincinnati, OH, November 2006.

Eghtesady P. Fetal Cardiovascular Research. Biomedical Engineering Department, University of Cincinnati, Cincinnati, OH, November 2006.

Eghtesady P. New Developments in Fetal Cardiac Surgery. Pediatric Cardiology Conference, Children's Hospital Medical Center, Cincinnati, OH, July 2006.

Eghtesady P. Fetal Cardiac Surgery: How Close Are We? Fetal Case Conference, Children's Hospital Medical Center, Cincinnati, OH May 2006.

Eghtesady P, Barlow C. Acute Cardiovascular Problems in Children: Collaborative Management of Children with Acute Illness. Wright State University, May, 2006.

Professional Organization Memberships

Books

Eghtesady P, Stevens J. The Intern Survival Guide to the Stanford Cardiac Surgery Service. 1994.

Eghtesady P. and Kronenberg M. The function of T-lymphocytes and the Non-classical class I molecules. 1992, University of California Publishing, Los Angeles, CA.

Hershberg R., Eghtesady P., Kronenberg M. Intestinal Lymphocytes and Epithelium express the Thymus Leukemia Antigen in The Immunology of the Gut from the Proceedings of International Congress on Mucosal Immunology V, Tokyo. 1990. Excerpta Medical International Congress Series, Elsevier Science Publishing BV.

Abstracts and Poster Presentations

Eghtesady P, Hall M. Mini-Epidemics of Hypoplastic Left Heart Syndrome. American College of Cardiology, 58th Annual Scientific Session. Orlando, FL. March 29-31, 2009. Selected for “Best Poster” Competition.

Duffy JY, Baker RS, Basu M, Reed C, Heeb EA, Eghtesady P. Myocardial Contractile Dysfunction is Associated with Fetal Cardiac Bypass in a Sheep Model. American Heart Association, Scientific Sessions. New Orleans, LA. November 8-12, 2008

Eghtesady P. Fetal Cardiac Surgery: Mission Impossible? 4th Annual International Symposium of Pediatric Mechanical Assist and Cardiopulmonary Bypass. Portland, OR. May 21-24, 2008

Eghtesady P, Michelfelder E, Knilans TK, Livingston J, Manning PB, Crombleholme T. Fetal Surgical Management of Congenital Heart Block in a Hydropic Fetus: Lessons Learned from a Clinical Experience. 4th Annual International Symposium of Pediatric Mechanical Assist and Cardiopulmonary Bypass. Portland, OR. May 21-24, 2008

Eghtesady P, Baker RS, Lam CT, Hilshorst JL, Ferguson RE, Lombardi JP. Dynamic Fluid Shifts Induced by Fetal Cardiopulmonary Bypass American Association of Thoracic Surgery San Diego, CA. May 11-14, 2008.

Basu M, Baker, Lam CT, Clark KE, Eghtesady P. Role of NOS and PDE5 in Placental Dysfunction Following Fetal Bypass. Society for Gynecologic Investigation 55th Annual Scientific Meeting, San Diego, CA. March 26-29, 2008.

Sideek H, Eghtesady P, Clark KE, Wagner CJ, Duffy JY. Serum Collected During and After Fetal Sheep Cardiopulmonary Bypass Stimulates Nitric Oxide and Endothelin-1 Production by Umbilical Vein Endothelial Cells. Society for Gynecologic Investigation 55th Annual Scientific Meeting, San Diego, CA. March 26-29, 2008.

Eghtesady P, Baker RS, Lam CT, Ross A, Hilshorst J, Ferguson RE, Gardner A, Lombardi J, Clark KE. Changes in Fetal Metabolism and Oxygen Delivery with Fetal Cardiac Surgery. Society of Thoracic Surgeons, Ft. Lauderdale, FL. January 28-30, 2008.

Lam C, Baker RS, Lubbers WC, Hilshorst JM, Ferguson RE, Lombardi JP, Eghtesady P. Brain Natriuretic Peptide (BNP), cGMP and Fetal Cardiopulmonary Bypass. Society of Thoracic Surgeons, Ft. Lauderdale, FL. January 28-30, 2008.

Heydarian H, Border W, Lam C, Deddens J, Manning P, Eghtesady P. Right Heart Anomalies Negatively Impact Survival in Neonates with Hypoplastic Left Heart Syndrome Undergoing Single Ventricle Palliation. American College of Cardiology, New Orleans, LA, March 2007.

Baker S, Lam C, Lubbers W, Clark K, Eghtesady P. Dobutamine Is the Optimal Inotrope for the Fetus. Society for Maternal-Fetal Medicine, San Francisco, CA, February 2007.

Lubbers W, Burman D, Baker S, Eghtesady P. Prognostic Value of Amniotic Fluid Brain Natriuretic Peptide (BNP) in Fetal Aortic Stenosis. Society for Maternal-Fetal Medicine, San Francisco, CA, February 2007.

Sharma S, Baker S, Spezzano L, Lam C, Lombardi, J, Ferguson R, Gardner A, McNamara J, Clark K, Eghtesady P. Fetal Stress Response to Cardiac Surgery and Cardiopulmonary Bypass. Society for Maternal-Fetal Medicine, San Francisco, CA, February 2007.

Lam C, Baker S, Lubbers W, Teuschler C, Lombardi, J, Ferguson R, Gardner A, McNamara J, Clark K, Eghtesady P. Role of Nitric Oxide And cGMP And PDE-5 In Placental Dysfunction Following Fetal Bypass. Society of Thoracic Surgeons, San Diego, CA, January 2007.

Baker S, Lam C, Lubbers W, Teuschler C, Lombardi, J, Ferguson R, Gardner A, McNamara J, Clark K, Eghtesady P. FMAP during CPB Correlates with Transient Increase in [NO]. Society of Thoracic Surgeons, San Diego, CA, January 2007.

Lam C, Baker S, Lubbers W, Spezzano L, Teuschler C, Lombardi J, Ferguson R, Gardner A, McNamara J, Clark K, Eghtesady P. Role of Nitric Oxide in Placental Dysfunction Following Fetal Cardiopulmonary Bypass. American Heart Association, Chicago, IL, November 2006.

Ashcraft TA, Jones K, Border WL, Eghtesady P, Pearl JM, Khoury P, Manning PB. Factors Affecting Long Term Risk of Aortic Arch Re-Coarctation Following the Norwood Operation. The Southern Thoracic Surgical Association 53rd Annual Meeting, Tucson, AZ, November 8-11, 2006.

Lam CT, Baker RS, Lubbers WC, Spezzano LC, Teuschler C, McNamara JL, Ferguson RE, Gardner A, Lombardi JP, Clark KE, Eghtesady P. Role of Nitric Oxide and cGMP in Placental Dysfunction following Fetal Bypass. Midwest Pediatric Cardiology Society, Columbus, OH, September, 2006.

Lam CT, Border WL, Heydarian H, Deddens JA, Manning PB, Eghtesady P. Influence of Gender in Norwood Palliation of Hypoplastic Left Heart Syndrome. Midwest Pediatric Cardiology Society, Columbus, OH, September, 2006.

Lam C, Baker S, Lubbers W, Spezzano L, Teuschler C, Lombardi J, Ferguson R, Gardner A, McNamara J, Clark K, Eghtesady P. Role of Nitric Oxide in Placental Dysfunction Following Fetal Bypass, ODICH Society Annual Meeting, Cleveland, OH, May 2006.

Ashcraft TA, Jones K, Border WL, Eghtesady P, Pearl JM, Khoury P, Manning PB. Factors Affecting Long Term Risk of Aortic Arch Re-Coarctation Following the Norwood Operation. ODICH Society Annual Meeting, Cleveland, OH, May 5-7, 2006.